"Trojan Horse" antibiotics could help fight superbugs

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A new antibiotic has shown promising results after bypassing several multidrug resistant bacteria in early clinical trials.

The trials were conducted on a total of 448 patients with kidney or urinary tract infections, according to a paper published in The Lancet.

The antibiotic, cefiderocol, was able to enter the bacteria as it hid among iron molecules.

Bacteria in our bodies usually look for iron molecules as our bodies' natural response to an infection is to create a low-iron environment, to stop the bacteria from multiplying.

Once cefiderocol is inside the bacteria, it is able to kill it as other antibiotics.

However, larger trials would still be needed to ensure the effectiveness of the "trojan horse" antibiotic.

RUNDOWN SHOWS:
1. "Trojan horse" antibiotics
2. Kidney and Urinary tract
3. The antibiotic entering the bacteria
4. The antibiotic killing the bacteria

VOICEOVER (in English):
"A new antibiotic has shown promising results after bypassing several multidrug resistant bacteria in early clinical trials."

"According to a paper published in The Lancet, the trials were conducted on a total of 448 patients with kidney or urinary tract infections."

"The antibiotic, cefiderocol, was able to enter the bacteria as it hid among iron molecules."

"Once cefiderocol is inside the bacteria, it is able to kill it as other antibiotics."

SOURCES: New Atlas, The Independent, The Lancet, BBC News, The Telegraph
https://newatlas.com/cefiderocol-new-antibiotic-human-trials/56991/
https://www.independent.co.uk/news/health/antibiotic-resistance-bacteria-infection-superbug-ecoli-uti-symptoms-lancet-a8601641.html
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(18)30554-1/fulltext
https://www.bbc.com/news/health-45983320
https://www.telegraph.co.uk/news/2018/10/26/new-trojan-horse-drug-proves-effective-against-antibiotic-resistant/